The dsRBP and inactive editor ADR-1 utilizes dsRNA binding to regulate A-to-I RNA editing across the C. elegans transcriptome

• Main Authors: Washburn, Michael C., Kakaradov, Boyko., Sundararaman, Balaji., Wheeler, Emily., Hoon, Shawn., Yeo, Gene W., Hundley, Heather A.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/102098; http://hdl.handle.net/10220/18837
• Institution: Nanyang Technological University

Inadequate adenosine-to-inosine editing of noncoding regions occurs in disease but is often uncorrelated with ADAR levels, underscoring the need to study deaminase-independent control of editing. C. elegans have two ADAR proteins, ADR-2 and the theoretically catalytically inactive ADR-1. Using high-...