The dsRBP and inactive editor ADR-1 utilizes dsRNA binding to regulate A-to-I RNA editing across the C. elegans transcriptome

Inadequate adenosine-to-inosine editing of noncoding regions occurs in disease but is often uncorrelated with ADAR levels, underscoring the need to study deaminase-independent control of editing. C. elegans have two ADAR proteins, ADR-2 and the theoretically catalytically inactive ADR-1. Using high-...

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Bibliographic Details
Main Authors: Washburn, Michael C., Kakaradov, Boyko., Sundararaman, Balaji., Wheeler, Emily., Hoon, Shawn., Yeo, Gene W., Hundley, Heather A.
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2014
Subjects:
Online Access:https://hdl.handle.net/10356/102098
http://hdl.handle.net/10220/18837
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Institution: Nanyang Technological University
Language: English