Variations of subunit ε of the mycobacterium tuberculosis F1Fo ATP synthase and a novel model for mechanism of action of the tuberculosis drug TMC207

• Main Authors: Rao, Srinivasa P. S., Biuković, Goran, Basak, Sandip, Manimekalai, Malathy Sony Subramanian, Rishikesan, Sankaranarayanan, Roessle, Manfred, Dick, Thomas, Hunke, Cornelia, Grüber, Gerhard
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/102134; http://hdl.handle.net/10220/16820
• Institution: Nanyang Technological University

The subunit ε of bacterial F1FO ATP synthases plays an important regulatory role in coupling and catalysis via conformational transitions of its C-terminal domain. Here we present the first low-resolution solution structure of ε of Mycobacterium tuberculosis (Mtε) F1FO ATP synthase and the nuclear m...