LDsplit : screening for cis-regulatory motifs stimulating meiotic recombination hotspots by analysis of DNA sequence polymorphisms

• Main Authors: Przytycka, Teresa M., Yang, Peng, Wu, Min, Guo, Jing, Kwoh, Chee Keong, Zheng, Jie
• Other Authors: School of Computer Engineering
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Engineering::Computer science and engineering
• Online Access: https://hdl.handle.net/10356/102188; http://hdl.handle.net/10220/19368
• Institution: Nanyang Technological University

Background: As a fundamental genomic element, meiotic recombination hotspot plays important roles in life sciences. Thus uncovering its regulatory mechanisms has broad impact on biomedical research. Despite the recent identification of the zinc finger protein PRDM9 and its 13-mer binding motif as ma...