Obtusilactone B from Machilus Thunbergii targets barrier-to-autointegration factor to treat cancer

• Main Authors: Kim, Wanil, Lyu, Ha-Na, Kwon, Hyun-Sook, Kim, Ye Seul, Lee, Kyung-Ha, Kim, Do-Yeon, Chakraborty, Goutam, Choi, Kwan Yong, Yoon, Ho Sup, Kim, Kyong-Tai
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: Biological Sciences
• Online Access: https://hdl.handle.net/10356/102247; http://hdl.handle.net/10220/19055
• Institution: Nanyang Technological University

Targeting specific molecules is a promising cancer treatment because certain types of cancer cells are dependent on specific oncogenes. This strategy led to the development of therapeutics that use monoclonal antibodies or small-molecule inhibitors. However, the continued development of novel molecu...