Synthetic multivalent antifungal peptides effective against fungi

• Main Authors: Lakshminarayanan, Rajamani, Liu, Shouping, Li, Jianguo, Nandhakumar, Muruganantham, Aung, Thet Tun, Goh, Eunice, Chang, Jamie Ya Ting, Saraswathi, Padhmanaban, Tang, Charles, Safie, Siti Radiah Binte, Lin, Lim Yih, Riezman, Howard, Lei, Zhou, Verma, Chandra S., Beuerman, Roger W.
• Other Authors: Khan, Rizwan H.
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: https://hdl.handle.net/10356/102430; http://hdl.handle.net/10220/18996
• Institution: Nanyang Technological University

Taking advantage of the cluster effect observed in multivalent peptides, this work describes antifungal activity and possible mechanism of action of tetravalent peptide (B4010) which carries 4 copies of the sequence RGRKVVRR through a branched lysine core. B4010 displayed better antifungal propertie...