Exposure to titanium dioxide nanoparticles induces autophagy in primary human keratinocytes

• Main Authors: Loo, Joachim Say Chye, Ng, Kee Woei, Zhao, Yun, Howe, Josephine L. C., Yu, Zhang, Leong, David Tai, Chu, Justin Jang Hann
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Engineering::Materials::Nanostructured materials
• Online Access: https://hdl.handle.net/10356/102453; http://hdl.handle.net/10220/18983
• Institution: Nanyang Technological University

Understanding the mechanisms of cell-nanomaterial interactions is vital in harnessing the potential of using nanomaterials in biomedical applications. By immuno-labeling of LC3 and TEM analysis, it is found that titanium dioxide nanoparticles are internalized by human keratinocytes and induce autoph...