Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging

• Main Authors: Zhou, Jin, Chong, Shu Yun, Lim, Andrea, Singh, Brijesh K., Sinha, Rohit A., Salmon, Adam B., Yen, Paul M.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Muscle; Aging; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/102485; http://hdl.handle.net/10220/47261
• Institution: Nanyang Technological University

Aging causes a general decline in cellular metabolic activity, and function in different tissues and whole body homeostasis. However, the understanding about the metabolomic and autophagy changes in skeletal muscle and heart during aging is still limited. We thus examined markers for macroautophagy,...