Continuous separation of multiple particles by negative and positive dielectrophoresis in a modified H-filter
The article presents a new application of the modified H-filter with insulating rectangular blocks using negative and positive DEP for separation of multiple particles in a continuous pressure-driven flow. The multiple insulating blocks fabricated along the main channel induce spatially nonuniform e...
Saved in:
Main Authors: | , |
---|---|
Other Authors: | |
Format: | Article |
Language: | English |
Published: |
2014
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/102763 http://hdl.handle.net/10220/19187 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Nanyang Technological University |
Language: | English |
id |
sg-ntu-dr.10356-102763 |
---|---|
record_format |
dspace |
spelling |
sg-ntu-dr.10356-1027632020-03-07T13:22:21Z Continuous separation of multiple particles by negative and positive dielectrophoresis in a modified H-filter Lewpiriyawong, Nuttawut Yang, Chun School of Mechanical and Aerospace Engineering DRNTU::Engineering::Mechanical engineering The article presents a new application of the modified H-filter with insulating rectangular blocks using negative and positive DEP for separation of multiple particles in a continuous pressure-driven flow. The multiple insulating blocks fabricated along the main channel induce spatially nonuniform electric fields which exert differential repulsive (negative) or attractive (positive) DEP forces on particles, depending on the size and the polarizability of particles relative to their suspending medium. As a result, particles of different sizes and polarizability can be separated into different outlets of the H-filter. Numerical simulations are also performed to analyze the effects of block gap and width on electric field distribution and DEP force characteristics near the insulating blocks so as to provide design guidelines for optimal structural dimensions of the microfluidic device. The device performance is demonstrated by separating a three-sized particles mixture, including 2 μm fluorescent particles with an attractive DEP force and both 5 and 10 μm nonfluorescent particles with differential repulsive DEP forces. High separation rate of 99% is successfully achieved. 2014-04-09T05:53:50Z 2019-12-06T20:59:58Z 2014-04-09T05:53:50Z 2019-12-06T20:59:58Z 2013 2013 Journal Article Lewpiriyawong, N., & Yang, C. (2014). Continuous separation of multiple particles by negative and positive dielectrophoresis in a modified H-filter. ELECTROPHORESIS, 35(5), 714-720. 0173-0835 https://hdl.handle.net/10356/102763 http://hdl.handle.net/10220/19187 10.1002/elps.201300429 en Electrophoresis © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
institution |
Nanyang Technological University |
building |
NTU Library |
country |
Singapore |
collection |
DR-NTU |
language |
English |
topic |
DRNTU::Engineering::Mechanical engineering |
spellingShingle |
DRNTU::Engineering::Mechanical engineering Lewpiriyawong, Nuttawut Yang, Chun Continuous separation of multiple particles by negative and positive dielectrophoresis in a modified H-filter |
description |
The article presents a new application of the modified H-filter with insulating rectangular blocks using negative and positive DEP for separation of multiple particles in a continuous pressure-driven flow. The multiple insulating blocks fabricated along the main channel induce spatially nonuniform electric fields which exert differential repulsive (negative) or attractive (positive) DEP forces on particles, depending on the size and the polarizability of particles relative to their suspending medium. As a result, particles of different sizes and polarizability can be separated into different outlets of the H-filter. Numerical simulations are also performed to analyze the effects of block gap and width on electric field distribution and DEP force characteristics near the insulating blocks so as to provide design guidelines for optimal structural dimensions of the microfluidic device. The device performance is demonstrated by separating a three-sized particles mixture, including 2 μm fluorescent particles with an attractive DEP force and both 5 and 10 μm nonfluorescent particles with differential repulsive DEP forces. High separation rate of 99% is successfully achieved. |
author2 |
School of Mechanical and Aerospace Engineering |
author_facet |
School of Mechanical and Aerospace Engineering Lewpiriyawong, Nuttawut Yang, Chun |
format |
Article |
author |
Lewpiriyawong, Nuttawut Yang, Chun |
author_sort |
Lewpiriyawong, Nuttawut |
title |
Continuous separation of multiple particles by negative and positive dielectrophoresis in a modified H-filter |
title_short |
Continuous separation of multiple particles by negative and positive dielectrophoresis in a modified H-filter |
title_full |
Continuous separation of multiple particles by negative and positive dielectrophoresis in a modified H-filter |
title_fullStr |
Continuous separation of multiple particles by negative and positive dielectrophoresis in a modified H-filter |
title_full_unstemmed |
Continuous separation of multiple particles by negative and positive dielectrophoresis in a modified H-filter |
title_sort |
continuous separation of multiple particles by negative and positive dielectrophoresis in a modified h-filter |
publishDate |
2014 |
url |
https://hdl.handle.net/10356/102763 http://hdl.handle.net/10220/19187 |
_version_ |
1681048022488711168 |