Continuous separation of multiple particles by negative and positive dielectrophoresis in a modified H-filter

The article presents a new application of the modified H-filter with insulating rectangular blocks using negative and positive DEP for separation of multiple particles in a continuous pressure-driven flow. The multiple insulating blocks fabricated along the main channel induce spatially nonuniform e...

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Main Authors: Lewpiriyawong, Nuttawut, Yang, Chun
Other Authors: School of Mechanical and Aerospace Engineering
Format: Article
Language:English
Published: 2014
Subjects:
Online Access:https://hdl.handle.net/10356/102763
http://hdl.handle.net/10220/19187
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1027632020-03-07T13:22:21Z Continuous separation of multiple particles by negative and positive dielectrophoresis in a modified H-filter Lewpiriyawong, Nuttawut Yang, Chun School of Mechanical and Aerospace Engineering DRNTU::Engineering::Mechanical engineering The article presents a new application of the modified H-filter with insulating rectangular blocks using negative and positive DEP for separation of multiple particles in a continuous pressure-driven flow. The multiple insulating blocks fabricated along the main channel induce spatially nonuniform electric fields which exert differential repulsive (negative) or attractive (positive) DEP forces on particles, depending on the size and the polarizability of particles relative to their suspending medium. As a result, particles of different sizes and polarizability can be separated into different outlets of the H-filter. Numerical simulations are also performed to analyze the effects of block gap and width on electric field distribution and DEP force characteristics near the insulating blocks so as to provide design guidelines for optimal structural dimensions of the microfluidic device. The device performance is demonstrated by separating a three-sized particles mixture, including 2 μm fluorescent particles with an attractive DEP force and both 5 and 10 μm nonfluorescent particles with differential repulsive DEP forces. High separation rate of 99% is successfully achieved. 2014-04-09T05:53:50Z 2019-12-06T20:59:58Z 2014-04-09T05:53:50Z 2019-12-06T20:59:58Z 2013 2013 Journal Article Lewpiriyawong, N., & Yang, C. (2014). Continuous separation of multiple particles by negative and positive dielectrophoresis in a modified H-filter. ELECTROPHORESIS, 35(5), 714-720. 0173-0835 https://hdl.handle.net/10356/102763 http://hdl.handle.net/10220/19187 10.1002/elps.201300429 en Electrophoresis © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic DRNTU::Engineering::Mechanical engineering
spellingShingle DRNTU::Engineering::Mechanical engineering
Lewpiriyawong, Nuttawut
Yang, Chun
Continuous separation of multiple particles by negative and positive dielectrophoresis in a modified H-filter
description The article presents a new application of the modified H-filter with insulating rectangular blocks using negative and positive DEP for separation of multiple particles in a continuous pressure-driven flow. The multiple insulating blocks fabricated along the main channel induce spatially nonuniform electric fields which exert differential repulsive (negative) or attractive (positive) DEP forces on particles, depending on the size and the polarizability of particles relative to their suspending medium. As a result, particles of different sizes and polarizability can be separated into different outlets of the H-filter. Numerical simulations are also performed to analyze the effects of block gap and width on electric field distribution and DEP force characteristics near the insulating blocks so as to provide design guidelines for optimal structural dimensions of the microfluidic device. The device performance is demonstrated by separating a three-sized particles mixture, including 2 μm fluorescent particles with an attractive DEP force and both 5 and 10 μm nonfluorescent particles with differential repulsive DEP forces. High separation rate of 99% is successfully achieved.
author2 School of Mechanical and Aerospace Engineering
author_facet School of Mechanical and Aerospace Engineering
Lewpiriyawong, Nuttawut
Yang, Chun
format Article
author Lewpiriyawong, Nuttawut
Yang, Chun
author_sort Lewpiriyawong, Nuttawut
title Continuous separation of multiple particles by negative and positive dielectrophoresis in a modified H-filter
title_short Continuous separation of multiple particles by negative and positive dielectrophoresis in a modified H-filter
title_full Continuous separation of multiple particles by negative and positive dielectrophoresis in a modified H-filter
title_fullStr Continuous separation of multiple particles by negative and positive dielectrophoresis in a modified H-filter
title_full_unstemmed Continuous separation of multiple particles by negative and positive dielectrophoresis in a modified H-filter
title_sort continuous separation of multiple particles by negative and positive dielectrophoresis in a modified h-filter
publishDate 2014
url https://hdl.handle.net/10356/102763
http://hdl.handle.net/10220/19187
_version_ 1681048022488711168