NIR photoresponsive crosslinked upconverting nanocarriers toward selective intracellular drug release
An NIR-responsive mesoporous silica coated upconverting nanoparticle (UCNP) conjugate is developed for controllable drug delivery and fluorescence imaging in living cells. In this work, antitumor drug doxorubicin (Dox) molecules are encapsulated within cross-linked photocaged mesoporous silica coate...
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sg-ntu-dr.10356-1028152020-03-07T12:34:55Z NIR photoresponsive crosslinked upconverting nanocarriers toward selective intracellular drug release Yang, Yanmei Velmurugan, Bhaarathy Liu, Xiaogang Xing, Bengang School of Physical and Mathematical Sciences DRNTU::Science::Physics An NIR-responsive mesoporous silica coated upconverting nanoparticle (UCNP) conjugate is developed for controllable drug delivery and fluorescence imaging in living cells. In this work, antitumor drug doxorubicin (Dox) molecules are encapsulated within cross-linked photocaged mesoporous silica coated UCNPs. Upon 980 nm light irradiation, Dox could be selectively released through the photocleavage of theo-nitrobenzyl (NB) caged linker by the converted UV emission from UCNPs. This NIR light-responsive nanoparticle conjugate demonstrates high efficiency for the controlled release of the drug in cancer cells. Upon functionalization of the nanocarrier with folic acid (FA), this photocaged FA-conjugated silica-UCNP nanocarrier will also allow targeted intracellular drug delivery and selective fluorescence imaging towards the cell lines with high level expression of folate receptor (FR). 2014-04-07T06:03:26Z 2019-12-06T21:00:42Z 2014-04-07T06:03:26Z 2019-12-06T21:00:42Z 2013 2013 Journal Article Yang, Y., Velmurugan, B., Liu, X., & Xing, B. (2013). NIR Photoresponsive Crosslinked Upconverting Nanocarriers Toward Selective Intracellular Drug Release. Small, 9(17), 2937-2944. 1613-6810 https://hdl.handle.net/10356/102815 http://hdl.handle.net/10220/19157 10.1002/smll.201201765 en Small © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
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DRNTU::Science::Physics Yang, Yanmei Velmurugan, Bhaarathy Liu, Xiaogang Xing, Bengang NIR photoresponsive crosslinked upconverting nanocarriers toward selective intracellular drug release |
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An NIR-responsive mesoporous silica coated upconverting nanoparticle (UCNP) conjugate is developed for controllable drug delivery and fluorescence imaging in living cells. In this work, antitumor drug doxorubicin (Dox) molecules are encapsulated within cross-linked photocaged mesoporous silica coated UCNPs. Upon 980 nm light irradiation, Dox could be selectively released through the photocleavage of theo-nitrobenzyl (NB) caged linker by the converted UV emission from UCNPs. This NIR light-responsive nanoparticle conjugate demonstrates high efficiency for the controlled release of the drug in cancer cells. Upon functionalization of the nanocarrier with folic acid (FA), this photocaged FA-conjugated silica-UCNP nanocarrier will also allow targeted intracellular drug delivery and selective fluorescence imaging towards the cell lines with high level expression of folate receptor (FR). |
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School of Physical and Mathematical Sciences |
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School of Physical and Mathematical Sciences Yang, Yanmei Velmurugan, Bhaarathy Liu, Xiaogang Xing, Bengang |
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Article |
author |
Yang, Yanmei Velmurugan, Bhaarathy Liu, Xiaogang Xing, Bengang |
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Yang, Yanmei |
title |
NIR photoresponsive crosslinked upconverting nanocarriers toward selective intracellular drug release |
title_short |
NIR photoresponsive crosslinked upconverting nanocarriers toward selective intracellular drug release |
title_full |
NIR photoresponsive crosslinked upconverting nanocarriers toward selective intracellular drug release |
title_fullStr |
NIR photoresponsive crosslinked upconverting nanocarriers toward selective intracellular drug release |
title_full_unstemmed |
NIR photoresponsive crosslinked upconverting nanocarriers toward selective intracellular drug release |
title_sort |
nir photoresponsive crosslinked upconverting nanocarriers toward selective intracellular drug release |
publishDate |
2014 |
url |
https://hdl.handle.net/10356/102815 http://hdl.handle.net/10220/19157 |
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