NIR photoresponsive crosslinked upconverting nanocarriers toward selective intracellular drug release

An NIR-responsive mesoporous silica coated upconverting nanoparticle (UCNP) conjugate is developed for controllable drug delivery and fluorescence imaging in living cells. In this work, antitumor drug doxorubicin (Dox) molecules are encapsulated within cross-linked photocaged mesoporous silica coate...

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Main Authors: Yang, Yanmei, Velmurugan, Bhaarathy, Liu, Xiaogang, Xing, Bengang
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2014
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Online Access:https://hdl.handle.net/10356/102815
http://hdl.handle.net/10220/19157
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1028152020-03-07T12:34:55Z NIR photoresponsive crosslinked upconverting nanocarriers toward selective intracellular drug release Yang, Yanmei Velmurugan, Bhaarathy Liu, Xiaogang Xing, Bengang School of Physical and Mathematical Sciences DRNTU::Science::Physics An NIR-responsive mesoporous silica coated upconverting nanoparticle (UCNP) conjugate is developed for controllable drug delivery and fluorescence imaging in living cells. In this work, antitumor drug doxorubicin (Dox) molecules are encapsulated within cross-linked photocaged mesoporous silica coated UCNPs. Upon 980 nm light irradiation, Dox could be selectively released through the photocleavage of theo-nitrobenzyl (NB) caged linker by the converted UV emission from UCNPs. This NIR light-responsive nanoparticle conjugate demonstrates high efficiency for the controlled release of the drug in cancer cells. Upon functionalization of the nanocarrier with folic acid (FA), this photocaged FA-conjugated silica-UCNP nanocarrier will also allow targeted intracellular drug delivery and selective fluorescence imaging towards the cell lines with high level expression of folate receptor (FR). 2014-04-07T06:03:26Z 2019-12-06T21:00:42Z 2014-04-07T06:03:26Z 2019-12-06T21:00:42Z 2013 2013 Journal Article Yang, Y., Velmurugan, B., Liu, X., & Xing, B. (2013). NIR Photoresponsive Crosslinked Upconverting Nanocarriers Toward Selective Intracellular Drug Release. Small, 9(17), 2937-2944. 1613-6810 https://hdl.handle.net/10356/102815 http://hdl.handle.net/10220/19157 10.1002/smll.201201765 en Small © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic DRNTU::Science::Physics
spellingShingle DRNTU::Science::Physics
Yang, Yanmei
Velmurugan, Bhaarathy
Liu, Xiaogang
Xing, Bengang
NIR photoresponsive crosslinked upconverting nanocarriers toward selective intracellular drug release
description An NIR-responsive mesoporous silica coated upconverting nanoparticle (UCNP) conjugate is developed for controllable drug delivery and fluorescence imaging in living cells. In this work, antitumor drug doxorubicin (Dox) molecules are encapsulated within cross-linked photocaged mesoporous silica coated UCNPs. Upon 980 nm light irradiation, Dox could be selectively released through the photocleavage of theo-nitrobenzyl (NB) caged linker by the converted UV emission from UCNPs. This NIR light-responsive nanoparticle conjugate demonstrates high efficiency for the controlled release of the drug in cancer cells. Upon functionalization of the nanocarrier with folic acid (FA), this photocaged FA-conjugated silica-UCNP nanocarrier will also allow targeted intracellular drug delivery and selective fluorescence imaging towards the cell lines with high level expression of folate receptor (FR).
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Yang, Yanmei
Velmurugan, Bhaarathy
Liu, Xiaogang
Xing, Bengang
format Article
author Yang, Yanmei
Velmurugan, Bhaarathy
Liu, Xiaogang
Xing, Bengang
author_sort Yang, Yanmei
title NIR photoresponsive crosslinked upconverting nanocarriers toward selective intracellular drug release
title_short NIR photoresponsive crosslinked upconverting nanocarriers toward selective intracellular drug release
title_full NIR photoresponsive crosslinked upconverting nanocarriers toward selective intracellular drug release
title_fullStr NIR photoresponsive crosslinked upconverting nanocarriers toward selective intracellular drug release
title_full_unstemmed NIR photoresponsive crosslinked upconverting nanocarriers toward selective intracellular drug release
title_sort nir photoresponsive crosslinked upconverting nanocarriers toward selective intracellular drug release
publishDate 2014
url https://hdl.handle.net/10356/102815
http://hdl.handle.net/10220/19157
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