Inorganic-base-mediated hydroamination of alkenyl oximes for the synthesis of cyclic nitrones

• Main Authors: Peng, Xingao, Tong, Benny Meng Kiat, Hirao, Hajime, Chiba, Shunsuke
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Chemistry::Organic chemistry
• Online Access: https://hdl.handle.net/10356/102850; http://hdl.handle.net/10220/19197
• Institution: Nanyang Technological University

A method based on hydroamination mediated by inorganic base was developed for the synthesis of cyclic nitrones from alkenyl oximes. DFT calculations of the reaction pathway suggested that this hydroamination could proceed through an unprecedented nucleophilic amination of the unactivated alkene by t...