Enzyme-responsive cell-penetrating peptides conjugated mesoporous silica quantum dots nanocarriers for controlled release of nucleus-targeted drug molecules and real-time intracellular fluorescence imaging of tumor cells

• Main Authors: Costa, Marianne, Yeow, Edwin K. L., Li, Jinming, Liu, Fang, Shao, Qing, Min, Yuanzeng, Xing, Bengang
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Chemistry::Biochemistry
• Online Access: https://hdl.handle.net/10356/102852; http://hdl.handle.net/10220/19217
• Institution: Nanyang Technological University

Here, a set of novel and personalized nanocarriers are presented for controlled nucleus-targeted antitumor drug delivery and real-time imaging of intracellular drug molecule trafficking by integrating an enzyme activatable cell penetrating peptide (CPP) with mesoporous silica coated quantum dots nan...