Near-infrared light-mediated photoactivation of a platinum antitumor prodrug and simultaneous cellular apoptosis imaging by upconversion-luminescent nanoparticles

• Main Authors: Min, Yuanzeng, Li, Jinming, Liu, Fang, Yeow, Edwin Kok Lee, Xing, Bengang
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Mathematics
• Online Access: https://hdl.handle.net/10356/102920; http://hdl.handle.net/10220/19136
• Institution: Nanyang Technological University

Platinum-based drugs are among the most active antitumor reagents in clinical practice; their application is limited by side effects and drug resistance. A novel and personalized near-infrared (NIR) light-activated nanoplatform is obtained by combining a photoactivatable platinum(IV) prodrug and a c...