Gold-catalyzed cycloisomerization and diels-alder reaction of 1,4,9-dienyne esters to 3 a,6-methanoisoindole esters with pro-inflammatory cytokine antagonist activity

• المؤلفون الرئيسيون: Susanti, Dewi, Liu, Li-Juan, Rao, Weidong, Lin, Sheng, Ma, Dik-Lung, Leung, Chung-Hang, Chan, Philip Wai Hong
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2015
• الموضوعات: DRNTU::Science::Chemistry::Physical chemistry::Catalysis
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/103024; http://hdl.handle.net/10220/25763

A synthetic method to prepare 3a,6-methanoisoindole esters efficiently by gold(I)-catalyzed tandem 1,2-acyloxy migration/Nazarov cyclization followed by Diels–Alder reaction of 1,4,9-dienyne esters is described. We also report the ability of one example to inhibit binding of tumor necrosis factor-α...