Synthesis of oxacyclic scaffolds via dual ruthenium hydride/Brønsted acid-catalyzed isomerization/cyclization of allylic ethers

• Main Authors: Hansen, Casper L., Ascic, Erhad, Ohm, Ragnhild G., Petersen, Rico, Hansen, Mette R., Madsen, Daniel, Tanner, David, Nielsen, Thomas E.
• Other Authors: Singapore Centre for Environmental Life Sciences Engineering
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Engineering::Environmental engineering
• Online Access: https://hdl.handle.net/10356/103032; http://hdl.handle.net/10220/19161
• Institution: Nanyang Technological University

A ruthenium hydride/Brønsted acid-catalyzed tandem sequence is reported for the synthesis of 1,3,4,9-tetrahydropyrano[3,4-b]indoles (THPIs) and related oxacyclic scaffolds. The process was designed on the premise that readily available allylic ethers would undergo sequential isomerization, first to...