Selective Impairment of Spatial Cognition Caused by Autoantibodies to the N-Methyl-d-Aspartate Receptor

• Main Authors: Chang, Eric H., Volpe, Bruce T., Mackay, Meggan, Aranow, Cynthia, Watson, Philip, Kowal, Czeslawa, Storbeck, Justin, Mattis, Paul, Berlin, RoseAnn, Chen, Huiyi, Mader, Simone, Huerta, Tomás S., Huerta, Patricio T., Diamond, Betty
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2015
• Online Access: https://hdl.handle.net/10356/103167; http://hdl.handle.net/10220/38717
• Institution: Nanyang Technological University

Patients with systemic lupus erythematosus (SLE) experience cognitive abnormalities in multiple domains including processing speed, executive function, and memory. Here we show that SLE patients carrying antibodies that bind DNA and the GluN2A and GluN2B subunits of the N-methyl-d-aspartate receptor...