p53-sensitive epileptic behavior and inflammation in Ft1 hypomorphic mice

• Main Authors: Vernì, Fiammetta, Saggio, Isabella, Burla, Romina, La Torre, Mattia, Zanetti, Giorgia, Bastianelli, Alex, Merigliano, Chiara, Del Giudice, Simona, Vercelli, Alessandro, Di Cunto, Ferdinando, Boido, Marina
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Biological sciences; Epilepsy; Aging
• Online Access: https://hdl.handle.net/10356/103393; http://hdl.handle.net/10220/47298
• Institution: Nanyang Technological University

Epilepsy is a complex clinical condition characterized by repeated spontaneous seizures. Seizures have been linked to multiple drivers including DNA damage accumulation. Investigation of epilepsy physiopathology in humans imposes ethical and practical limitations, for this reason model systems are m...