Regulation of the NRF2 transcription factor by andrographolide and organic extracts from plant endophytes

• Main Authors: Wong, Daphne Pei Wen, Ng, Mei Ying, Leung, Jia Yu, Boh, Boon Kim, Lim, Ee Chien, Tan, Shi Hua, Lim, Shuying, Seah, Wen Hui, Hu, Christine Zhiwen, Ho, Boon Chuan, Ng, Daphne Hui Ping, Hagen, Thilo
• Other Authors: Massiah, Michael
• Format: Article
• Language: English
• Published: 2019
• Subjects: Andrographolide; DRNTU::Engineering::Environmental engineering; NRF2
• Online Access: https://hdl.handle.net/10356/103401; http://hdl.handle.net/10220/47309
• Institution: Nanyang Technological University

The transcription factor NF-E2 Related Factor-2 (NRF2) is an important drug target. Activation of NRF2 has chemopreventive effects in cancer and exerts beneficial effects in a number of diseases, including neurodegenerative diseases, inflammatory diseases, hepatosteatosis, obesity and insulin resist...