Reduced mRNA and protein expression levels of Tet Methylcytosine Dioxygenase 3 in endothelial progenitor cells of patients of type 2 diabetes with peripheral artery disease

• Main Authors: Zhao, Shi, Jia, Ting, Tang, Yang, Zhang, Xiaotong, Mao, Hong, Tian, Xiaojia, Li, Rui, Ma, Lu, Chen, Guoxun
• Other Authors: School of Social Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Tet Methylcytosine Dioxygenases; Endothelial Progenitor Cells; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/103405; http://hdl.handle.net/10220/47305
• Institution: Nanyang Technological University

Endothelial progenitor cells (EPCs) with immunological properties repair microvasculature to prevent the complications in patients with diabetes. Epigenetic changes such as DNA methylation alter the functions of cells. Tet methylcytosine dioxygenases (TETs) are enzymes responsible for the demethylat...