Enantioconvergent halogenophilic nucleophilic substitution (SN2X) reaction by chiral phase-transfer catalysis

• Main Author: Zhang, Xin
• Other Authors: Tan Choon Hong
• Format: Theses and Dissertations
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Chemistry
• Online Access: https://hdl.handle.net/10356/103434; http://hdl.handle.net/10220/48077
• Institution: Nanyang Technological University

Bimolecular nucleophilic substitution (SN2) is a well-known textbook reaction and considered carbonophilic as the nucleophile (Nu) attacks the electrophile C-X bond from the ‘backside’ subsequently displacing X. Another form of substitution, that is less known, is the halogenophilic nucleophilic sub...