Multifocal noncontact color imaging for depth-sensitive fluorescence measurements of epithelial cancer

Multifocal noncontact color imaging for depth-sensitive fluorescence measurements of epithelial cancer

We propose a multifocal noncontact setup to perform depth-sensitive fluorescence imaging on a two-layered epithelial tissue model. The combination of a microlens array and a tunable lens enables the depth of the multifocal plane to be conveniently adjusted without any mechanical movement of the imag...

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Bibliographic Details
Main Authors: Zhu, Caigang, Ong, Yi Hong, Liu, Quan
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2014
Subjects:
DRNTU::Science::Medicine::Optical instruments
DRNTU::Engineering::Bioengineering
Online Access:https://hdl.handle.net/10356/103467
http://hdl.handle.net/10220/20001
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Institution: Nanyang Technological University
Language: English
Description
Summary:We propose a multifocal noncontact setup to perform depth-sensitive fluorescence imaging on a two-layered epithelial tissue model. The combination of a microlens array and a tunable lens enables the depth of the multifocal plane to be conveniently adjusted without any mechanical movement of the imaging lens or the sample. This advantage is particularly desirable in the clinical setting. Results from the phantom study demonstrate that the setup can achieve depth-sensitive color imaging for fluorescence measurements, which is further confirmed by spectral measurements.

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