Pomegranate activates TFEB to promote autophagy-lysosomal fitness and mitophagy

• Main Authors: Tan, Sijie, Yu, Chye Yun, Sim, Zhi Wei, Low, Zun Siong, Lee, Brianna, See, Faith, Min, Nyo, Gautam, Archana, Chu, Justin Jang Hann, Ng, Kee Woei, Wong, Esther
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2019
• Subjects: Cellular Neuroscience; Macroautophagy; DRNTU::Engineering::Materials
• Online Access: https://hdl.handle.net/10356/103470; http://hdl.handle.net/10220/48091
• Institution: Nanyang Technological University

Mitochondrial dysfunction underscores aging and diseases. Mitophagy (mitochondria + autophagy) is a quality control pathway that preserves mitochondrial health by targeting damaged mitochondria for autophagic degradation. Hence, molecules or compounds that can augment mitophagy are therapeutic candi...