(1-aryloxy-2-hydroxypropyl)-phenylpiperazine derivatives suppress Candida albicans virulence by interfering with morphological transition

• Main Authors: Zhao, Shuo, Huang, Jun-Jun, Sun, Xiuyun, Huang, Xiaorong, Fu, Shuna, Yang, Liang, Liu, Xue-Wei, He, Fei, Deng, Yinyue
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Candida Albicans; Morphological Transition; DRNTU::Science::Chemistry
• Online Access: https://hdl.handle.net/10356/103490; http://hdl.handle.net/10220/47335
• Institution: Nanyang Technological University

Clinical treatment of Candida albicans infections has become more difficult due to the limited development of antifungal agents and the rapid emergence of drug resistance. In this study, we demonstrate the synthesis of a series of piperazine derivatives and the evaluation of their inhibitory activit...