Iminoiodane- and Brønsted Base-Mediated Cross Dehydrogenative Coupling of Cyclic Ethers with 1,3-Dicarbonyl Compounds
A one-pot, two-step approach to prepare 2-tetrahydrofuran and -pyran substituted 1,3-dicarbonyl compounds by PhI=NTs-mediated amination/Brønsted base-catalyzed cross dehydrogenative coupling (CDC) reaction of the cyclic ether and 1,3-dicarbonyl derivative under mild conditions is reported. The react...
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2015
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sg-ntu-dr.10356-1035222023-02-28T19:44:18Z Iminoiodane- and Brønsted Base-Mediated Cross Dehydrogenative Coupling of Cyclic Ethers with 1,3-Dicarbonyl Compounds Chan, Philip Wai Hong Tejo, Ciputra Sim, Xiao Rong Lee, Bo Ra Ayers, Benjamin James Leung, Chung-Hang Ma, Dik-Lung School of Physical and Mathematical Sciences A one-pot, two-step approach to prepare 2-tetrahydrofuran and -pyran substituted 1,3-dicarbonyl compounds by PhI=NTs-mediated amination/Brønsted base-catalyzed cross dehydrogenative coupling (CDC) reaction of the cyclic ether and 1,3-dicarbonyl derivative under mild conditions is reported. The reaction is compatible with a variety of cyclic ethers and 1,3-dicarbonyl compounds, affording the corresponding coupled products in moderate to good yields of up to 80% over two steps. Published version 2015-10-01T07:46:11Z 2019-12-06T21:14:29Z 2015-10-01T07:46:11Z 2019-12-06T21:14:29Z 2015 2015 Journal Article Tejo, C., Sim, X., Lee, B., Ayers, B., Leung, C. H., Ma, D. L., et al. (2015). Iminoiodane- and Brønsted Base-Mediated Cross Dehydrogenative Coupling of Cyclic Ethers with 1,3-Dicarbonyl Compounds. Molecules, 20(7), 13336-13353. 1420-3049 https://hdl.handle.net/10356/103522 http://hdl.handle.net/10220/38771 10.3390/molecules200713336 en Molecules © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). application/pdf |
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A one-pot, two-step approach to prepare 2-tetrahydrofuran and -pyran substituted 1,3-dicarbonyl compounds by PhI=NTs-mediated amination/Brønsted base-catalyzed cross dehydrogenative coupling (CDC) reaction of the cyclic ether and 1,3-dicarbonyl derivative under mild conditions is reported. The reaction is compatible with a variety of cyclic ethers and 1,3-dicarbonyl compounds, affording the corresponding coupled products in moderate to good yields of up to 80% over two steps. |
| author2 |
School of Physical and Mathematical Sciences |
| author_facet |
School of Physical and Mathematical Sciences Chan, Philip Wai Hong Tejo, Ciputra Sim, Xiao Rong Lee, Bo Ra Ayers, Benjamin James Leung, Chung-Hang Ma, Dik-Lung |
| format |
Article |
| author |
Chan, Philip Wai Hong Tejo, Ciputra Sim, Xiao Rong Lee, Bo Ra Ayers, Benjamin James Leung, Chung-Hang Ma, Dik-Lung |
| spellingShingle |
Chan, Philip Wai Hong Tejo, Ciputra Sim, Xiao Rong Lee, Bo Ra Ayers, Benjamin James Leung, Chung-Hang Ma, Dik-Lung Iminoiodane- and Brønsted Base-Mediated Cross Dehydrogenative Coupling of Cyclic Ethers with 1,3-Dicarbonyl Compounds |
| author_sort |
Chan, Philip Wai Hong |
| title |
Iminoiodane- and Brønsted Base-Mediated Cross Dehydrogenative Coupling of Cyclic Ethers with 1,3-Dicarbonyl Compounds |
| title_short |
Iminoiodane- and Brønsted Base-Mediated Cross Dehydrogenative Coupling of Cyclic Ethers with 1,3-Dicarbonyl Compounds |
| title_full |
Iminoiodane- and Brønsted Base-Mediated Cross Dehydrogenative Coupling of Cyclic Ethers with 1,3-Dicarbonyl Compounds |
| title_fullStr |
Iminoiodane- and Brønsted Base-Mediated Cross Dehydrogenative Coupling of Cyclic Ethers with 1,3-Dicarbonyl Compounds |
| title_full_unstemmed |
Iminoiodane- and Brønsted Base-Mediated Cross Dehydrogenative Coupling of Cyclic Ethers with 1,3-Dicarbonyl Compounds |
| title_sort |
iminoiodane- and brønsted base-mediated cross dehydrogenative coupling of cyclic ethers with 1,3-dicarbonyl compounds |
| publishDate |
2015 |
| url |
https://hdl.handle.net/10356/103522 http://hdl.handle.net/10220/38771 |
| _version_ |
1759855008922206208 |