Organ-specific fate, recruitment, and refilling dynamics of tissue-resident macrophages during blood-stage Malaria

• Main Authors: Lai, Si Min, Sheng, Jianpeng, Gupta, Pravesh, Renia, Laurent, Duan, Kaibo, Zolezzi, Francesca, Karjalainen, Klaus, Newell, Evan W., Ruedl, Christiane
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Biological sciences; Tissue-resident Macrophages; Kupffer Cells
• Online Access: https://hdl.handle.net/10356/103556; http://hdl.handle.net/10220/47350
• Institution: Nanyang Technological University

Inflammation-induced disappearance of tissue-resident macrophages represents a key pathogen defense mechanism. Using a model of systemic blood-stage malaria, we studied the dynamics of tissue-resident macrophages in multiple organs to determine how they are depleted and refilled during the course of...