Overexpression of GRB2 enhances epithelial to mesenchymal transition of A549 cells by upregulating SNAIL expression

Overexpression of GRB2 enhances epithelial to mesenchymal transition of A549 cells by upregulating SNAIL expression

GRB2 is an adaptor protein which interacts with phosphorylated TGF-β receptor and is critical for mammary tumour growth. We found that TGF-β1-induced EMT increased GRB2 expression in A549 cells (non-small cell lung cancer). Overexpression of GRB2 (A549GRB2) enhanced cell invasion while knocking down...

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Bibliographic Details
Main Authors: Mitra, Payal, Kalailingam, Pazhanichamy, Thanabalu, Thirumaran, Tan, Hui Bing
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2019
Subjects:
E-cadherin
Cell Adhesion
DRNTU::Science::Biological sciences
Online Access:https://hdl.handle.net/10356/103566
http://hdl.handle.net/10220/47362
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/103566
http://hdl.handle.net/10220/47362

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