Targeting metabolic flexibility via angiopoietin-like 4 protein sensitizes metastatic cancer cells to chemotherapy drugs

• Main Authors: Lim, Maegan Miang Kee, Wee, Jonathan Wei Kiat, Soong, Jen Chi, Chua, Damien, Tan, Wei Ren, Lizwan, Marco, Li, Yinliang, Teo, Ziqiang, Goh, Wilson Wen Bin, Zhu, Pengcheng, Tan, Nguan Soon
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Biological sciences; Multi-drug Resistance; Epithelial-mesenchymal Transition
• Online Access: https://hdl.handle.net/10356/103567; http://hdl.handle.net/10220/47340
• Institution: Nanyang Technological University

Overcoming multidrug resistance has always been a major challenge in cancer treatment. Recent evidence suggested epithelial-mesenchymal transition plays a role in MDR, but the mechanism behind this link remains unclear. We found that the expression of multiple ABC transporters was elevated in concor...