Single-cell transcriptome analysis reveals estrogen signaling coordinately augments one-carbon, polyamine, and purine synthesis in breast cancer

• Main Authors: Zhu, Detu, Zhao, Zuxianglan, Cui, Guimei, Chang, Shiehong, Hu, Lingling, See, Yi Xiang, Lim, Michelle Gek Liang, Guo, Dajiang, Chen, Xin, Robson, Paul, Luo, Yumei, Cheung, Edwin
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Breast Cancer; Single-Cell Transcriptome; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/103569; http://hdl.handle.net/10220/47361
• Institution: Nanyang Technological University

Estrogen drives breast cancer (BCa) progression by directly activating estrogen receptor α (ERα). However, because of the stochastic nature of gene transcription, it is important to study the estrogen signaling pathway at the single-cell level to fully understand how ERα regulates transcription. Her...