Single nucleotide polymorphisms in Plasmodium falciparum V type H(+) pyrophosphatase gene (pfvp2) and their associations with pfcrt and pfmdr1 polymorphisms

• Main Authors: Jovel, Irina Tatiana, Ferreira, Pedro Eduardo, Veiga, Maria Isabel, Malmberg, Maja, Mårtensson, Andreas, Kaneko, Akira, Zakeri, Sedigheh, Murillo, Claribel, Nosten, Francois, Björkman, Anders, Ursing, Johan
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/103595; http://hdl.handle.net/10220/19345
• Institution: Nanyang Technological University

Background Chloroquine resistance in Plasmodium falciparum malaria has been associated with pfcrt 76T (chloroquine resistance transporter gene) and pfmdr1 86Y (multidrug resistance gene 1) alleles. Pfcrt 76T enables transport of protonated chloroquine out of the parasites digestive vacuole result...