Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms

Abdominal aortic aneurysms (AAAs) occur because of dilation of the infra-renal aorta to more than 150% of its initial diameter. Progression to rupture is aided by several pathophysiological and biomechanical factors. Surgical intervention is recommended when the aneurysm maximum transverse diameter...

Full description

Saved in:
Bibliographic Details
Main Authors: Canchi, Tejas, Saxena, Ashish, Narayanan, Sriram, Pwee, Esley Chin Hock, Ng, Eddie Yin Kwee
Other Authors: School of Mechanical and Aerospace Engineering
Format: Article
Language:English
Published: 2019
Subjects:
Online Access:https://hdl.handle.net/10356/103638
http://hdl.handle.net/10220/49494
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-103638
record_format dspace
spelling sg-ntu-dr.10356-1036382023-03-04T17:20:34Z Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms Canchi, Tejas Saxena, Ashish Narayanan, Sriram Pwee, Esley Chin Hock Ng, Eddie Yin Kwee School of Mechanical and Aerospace Engineering Fluid–Structure Interaction Abdominal Aortic Aneurysm Abdominal aortic aneurysms (AAAs) occur because of dilation of the infra-renal aorta to more than 150% of its initial diameter. Progression to rupture is aided by several pathophysiological and biomechanical factors. Surgical intervention is recommended when the aneurysm maximum transverse diameter (DAAA) exceeds 55 mm. A system model that incorporates biomechanical parameters will improve prognosis and establish a relationship between AAA geometry and rupture risk. Two Asian patient-specific AAA geometries were obtained from an IRB-approved vascular database. A biomechanical model based on the fluid–structure interaction (FSI) method was developed for a small aneurysm with DAAA of 35 mm and a large aneurysm with a corresponding diameter of 75 mm. The small aneurysm (patient 1) developed a maximum principal stress (PS1) of 3.16e5 Pa and the large aneurysm (patient 2) developed a PS1 of 2.32e5 Pa. Maximum deformation of arterial wall was 0.0020 m and 0.0022 m for patients 1 and 2 respectively. Location of maximum integral wall shear stress (WSS) (fluid) was different from that of PS1. Induced WSS was also higher in patient 1 (18.74 Pa vs 12.88 Pa). An FSI model incorporating the effect of both the structural and fluid domains aids in better understanding of the mechanics of AAA rupture. Patient 1, having a lower DAAA than patient 2, developed a larger PS1 and WSS. It may be concluded that DAAA may not be the sole determinant of AAA rupture risk. Accepted version 2019-07-31T01:08:44Z 2019-12-06T21:16:51Z 2019-07-31T01:08:44Z 2019-12-06T21:16:51Z 2018 Journal Article Canchi, T., Saxena, A., Ng, E. Y. K., Pwee, E. C.H., & Narayanan, S. (2018). Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms. BioNanoScience, 8(4), 1035-1044. doi:10.1007/s12668-018-0554-z 2191-1630 https://hdl.handle.net/10356/103638 http://hdl.handle.net/10220/49494 10.1007/s12668-018-0554-z en BioNanoScience © 2018 Springer Science+Business Media, LLC, part of Springer Nature. 27 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Fluid–Structure Interaction
Abdominal Aortic Aneurysm
spellingShingle Fluid–Structure Interaction
Abdominal Aortic Aneurysm
Canchi, Tejas
Saxena, Ashish
Narayanan, Sriram
Pwee, Esley Chin Hock
Ng, Eddie Yin Kwee
Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms
description Abdominal aortic aneurysms (AAAs) occur because of dilation of the infra-renal aorta to more than 150% of its initial diameter. Progression to rupture is aided by several pathophysiological and biomechanical factors. Surgical intervention is recommended when the aneurysm maximum transverse diameter (DAAA) exceeds 55 mm. A system model that incorporates biomechanical parameters will improve prognosis and establish a relationship between AAA geometry and rupture risk. Two Asian patient-specific AAA geometries were obtained from an IRB-approved vascular database. A biomechanical model based on the fluid–structure interaction (FSI) method was developed for a small aneurysm with DAAA of 35 mm and a large aneurysm with a corresponding diameter of 75 mm. The small aneurysm (patient 1) developed a maximum principal stress (PS1) of 3.16e5 Pa and the large aneurysm (patient 2) developed a PS1 of 2.32e5 Pa. Maximum deformation of arterial wall was 0.0020 m and 0.0022 m for patients 1 and 2 respectively. Location of maximum integral wall shear stress (WSS) (fluid) was different from that of PS1. Induced WSS was also higher in patient 1 (18.74 Pa vs 12.88 Pa). An FSI model incorporating the effect of both the structural and fluid domains aids in better understanding of the mechanics of AAA rupture. Patient 1, having a lower DAAA than patient 2, developed a larger PS1 and WSS. It may be concluded that DAAA may not be the sole determinant of AAA rupture risk.
author2 School of Mechanical and Aerospace Engineering
author_facet School of Mechanical and Aerospace Engineering
Canchi, Tejas
Saxena, Ashish
Narayanan, Sriram
Pwee, Esley Chin Hock
Ng, Eddie Yin Kwee
format Article
author Canchi, Tejas
Saxena, Ashish
Narayanan, Sriram
Pwee, Esley Chin Hock
Ng, Eddie Yin Kwee
author_sort Canchi, Tejas
title Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms
title_short Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms
title_full Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms
title_fullStr Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms
title_full_unstemmed Application of fluid–structure interaction methods to estimate the mechanics of rupture in Asian abdominal aortic aneurysms
title_sort application of fluid–structure interaction methods to estimate the mechanics of rupture in asian abdominal aortic aneurysms
publishDate 2019
url https://hdl.handle.net/10356/103638
http://hdl.handle.net/10220/49494
_version_ 1759856734469357568