Dengue vaccines : dawning at last?

The need for a dengue vaccine is more pressing than ever. Dengue—a mosquito-borne viral infection caused by any of the four dengue virus serotypes—is regarded as the most important arboviral disease globally, because more than 50% of the world's population live in regions at risk of the disease...

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Bibliographic Details
Main Author: Wilder-Smith, Annelies
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2015
Subjects:
Online Access:https://hdl.handle.net/10356/103775
http://hdl.handle.net/10220/24583
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Institution: Nanyang Technological University
Language: English
Description
Summary:The need for a dengue vaccine is more pressing than ever. Dengue—a mosquito-borne viral infection caused by any of the four dengue virus serotypes—is regarded as the most important arboviral disease globally, because more than 50% of the world's population live in regions at risk of the disease, and evidence points towards further geographical and numerical expansion.1 The results of Maria Capeding and colleagues' multicentre phase 3, randomised, observer-masked, placebo-controlled efficacy trial2 for a recombinant, chimeric, live attenuated tetravalent dengue vaccine (CYD-TDV), in The Lancet, have been awaited with great anticipation paired with some trepidation, on the basis of the disappointing results from a previous single-centre trial with the same vaccine in Thailand.