Nucleophilic β-carbon activation of propionic acid as a 3-carbon synthon by carbene organocatalysis

Nucleophilic β-carbon activation of propionic acid as a 3-carbon synthon by carbene organocatalysis

Direct β-carbon activation of propionic acid (C2H5CO2H) by carbene organocatalysis has been developed. This activation affords the smallest azolium homoenolate intermediate (without any substituent) as a 3-carbon nucleophile for enantioselective reactions. Propionic acid is an excellent raw material...

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Bibliographic Details
Main Authors: Chi, Robin Yonggui, Jin, Zhichao, Jiang, Ke, Fu, Zhenqian, Torres, Jaume, Zheng, Pengcheng, Yang, Song, Song, Bao-An
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2015
Subjects:
DRNTU::Science::Chemistry::Organic chemistry
Online Access:https://hdl.handle.net/10356/103784
http://hdl.handle.net/10220/25876
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/103784
http://hdl.handle.net/10220/25876

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