Chiral bicyclic guanidine-catalysed conjugate addition of α-fluoro-β-ketoesters to cyclic enones

• Main Authors: Jing, Zhenzhong, Liu, Jin, Chin, Kek Foo, Chen, Wenchao, Tan, Choon-Hong, Jiang, Zhiyong
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Chemistry::Organic chemistry
• Online Access: https://hdl.handle.net/10356/103798; http://hdl.handle.net/10220/24556
• Institution: Nanyang Technological University

By utilising a chiral bicyclic guanidine as catalyst and triethylamine as additive, the first asymmetric Michael addition of α-fluoro-β-ketoesters to various cyclic enones has been successfully developed, affording a variety of Michael adducts with potential synthetic utilities with satisfactory ste...