A major population of mucosal memory CD4+ T cells, coexpressing IL-18Rα and DR3, display innate lymphocyte functionality

• Main Authors: Holmkvist, P., Roepstorff, K., Uronen-Hansson, H., Sandén, C., Gudjonsson, S., Patschan, O., Grip, O., Marsal, J., Schmidtchen, A., Hornum, L., Erjefält, J. S., Håkansson, K., Agace, W W.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Immunology
• Online Access: https://hdl.handle.net/10356/103806; http://hdl.handle.net/10220/24590
• Institution: Nanyang Technological University

Mucosal tissues contain large numbers of memory CD4+ T cells that, through T-cell receptor-dependent interactions with antigen-presenting cells, are believed to have a key role in barrier defense and maintenance of tissue integrity. Here we identify a major subset of memory CD4+ T cells at barrier s...