Two different conformations in hepatitis C virus p7 protein account for proton transport and dye release

• Main Authors: Gan, Siok Wan, Surya, Wahyu, Vararattanavech, Ardcharaporn, Torres, Jaume
• Other Authors: Waris, Gulam
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: https://hdl.handle.net/10356/104025; http://hdl.handle.net/10220/19385
• Institution: Nanyang Technological University

The p7 protein from the hepatitis C virus (HCV) is a 63 amino acid long polypeptide that is essential for replication, and is involved in protein trafficking and proton transport. Therefore, p7 is a possible target for antivirals. The consensus model for the channel formed by p7 protein is a hexamer...