Nitrous oxide production in sputum from cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection

• Main Authors: Hansen, Christine Rønne, Liengaard, Lars, Kolpen, Mette, Kühl, Michael, Bjarnsholt, Thomas, Moser, Claus, Kharazmi, Arsalan, Pressler, Tanja, Høiby, Niels, Jensen, Peter Østrup
• Other Authors: Gulbins, Erich
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/104137; http://hdl.handle.net/10220/19555
• Institution: Nanyang Technological University

Chronic lung infection by Pseudomonas aeruginosa is the major severe complication in cystic fibrosis (CF) patients, where P. aeruginosa persists and grows in biofilms in the endobronchial mucus under hypoxic conditions. Numerous polymorphonuclear leukocytes (PMNs) surround the biofilms and create lo...