Imaging analysis of human metapneumovirus-infected cells provides evidence for the involvement of F-actin and the raft-lipid microdomains in virus morphogenesis

• Main Authors: Jumat, Muhammad Raihan, Nguyen Huong, Tra, Wong, Puisan, Loo, Liat Hui, Tan, Boon Huan, Fenwick, Fiona, Toms, Geoffrey L., Sugrue, Richard J.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: Human metapneumovirus; Virus filaments; Paramyxovirus; Virus assembly; Lipid-raft; F-actin
• Online Access: https://hdl.handle.net/10356/104297; http://hdl.handle.net/10220/38817
• Institution: Nanyang Technological University

Backgound: Due to difficulties of culturing Human metapneumovirus (HMPV) much of the current understanding of HMPV replication can be inferred from other closely related viruses. The slow rates of virus replication prevent many biochemical analyses of HMPV particles. In this study imaging was used t...