Evidence for a role of the polysaccharide capsule transport proteins in pertussis pathogenesis

• Main Authors: Hoo, Regina, Lam, Jian Hang, Huot, Ludovic, Pant, Aakanksha, Li, Rui, Hot, David, Alonso, Sylvie
• Other Authors: Hozbor, Daniela Flavia
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Bacteria
• Online Access: https://hdl.handle.net/10356/104381; http://hdl.handle.net/10220/24600
• Institution: Nanyang Technological University

Polysaccharide (PS) capsules are important virulence determinants for many bacterial pathogens. Bordetella pertussis, the agent of whooping cough, produces a surface associated microcapsule but its role in pertussis pathogenesis remained unknown. Here we showed that the B. pertussis capsule locus is...