Ribosome protection by ABC‐F proteins — molecular mechanism and potential drug design

• Main Authors: Ero, Rya, Kumar, Veerendra, Su, Weixin, Gao, Yong‐Gui
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Antibiotic Resistance; Ribosome Protection; Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/104616; http://hdl.handle.net/10220/49511
• Institution: Nanyang Technological University

Members of the ATP‐binding cassette F (ABC‐F) proteins confer resistance to several classes of clinically important antibiotics through ribosome protection. Recent structures of two ABC‐F proteins, Pseudomonas aeruginosa MsrE and Bacillus subtilis VmlR bound to ribosome have shed light onto the ribo...