Crystal structure of human vaccinia-related kinase 1 in complex with AMP-PNP, a non-hydrolyzable ATP analog

Crystal structure of human vaccinia-related kinase 1 in complex with AMP-PNP, a non-hydrolyzable ATP analog

Vaccinia‐related kinase 1 (VRK1), a serine/threonine mitotic kinase, is widely over‐expressed in dividing cells and regarded as a cancer drug target primarily due to its function as an early response gene in cell proliferation. However, the mechanism of VRK1 phosphorylation and substrate activation...

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Bibliographic Details
Main Authors: Ngow, Yeen Shian, Rajan, Sreekanth, Ye, Hong, Yoon, Ho Sup
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2019
Subjects:
Kinase
Mitotic Kinase
Science::Biological sciences
Online Access:https://hdl.handle.net/10356/104629
http://hdl.handle.net/10220/49509
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/104629
http://hdl.handle.net/10220/49509

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