GPU-accelerated two dimensional synthetic aperture focusing for photoacoustic microscopy

Acoustic resolution photoacoustic microscopy (AR-PAM) generally suffers from limited depth of focus, which had been extended by synthetic aperture focusing techniques (SAFTs). However, for three dimensional AR-PAM, current one dimensional (1D) SAFT and its improved version like cross-shaped SAFT do...

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Main Authors: Liu, Siyu, Feng, Xiaohua, Gao, Fei, Jin, Haoran, Zhang, Ruochong, Luo, Yunqi, Zheng, Yuanjin
Other Authors: School of Electrical and Electronic Engineering
Format: Article
Language:English
Published: 2019
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Online Access:https://hdl.handle.net/10356/104699
http://hdl.handle.net/10220/50300
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1046992020-03-07T14:02:44Z GPU-accelerated two dimensional synthetic aperture focusing for photoacoustic microscopy Liu, Siyu Feng, Xiaohua Gao, Fei Jin, Haoran Zhang, Ruochong Luo, Yunqi Zheng, Yuanjin School of Electrical and Electronic Engineering Photoacoustic Effects Acoustic Transducers DRNTU::Engineering::Electrical and electronic engineering Acoustic resolution photoacoustic microscopy (AR-PAM) generally suffers from limited depth of focus, which had been extended by synthetic aperture focusing techniques (SAFTs). However, for three dimensional AR-PAM, current one dimensional (1D) SAFT and its improved version like cross-shaped SAFT do not provide isotropic resolution in the lateral direction. The full potential of the SAFT remains to be tapped. To this end, two dimensional (2D) SAFT with fast computing architecture is proposed in this work. Explained by geometric modeling and Fourier acoustics theories, 2D-SAFT provide the narrowest post-focusing capability, thus to achieve best lateral resolution. Compared with previous 1D-SAFT techniques, the proposed 2D-SAFT improved the lateral resolution by at least 1.7 times and the signal-to-noise ratio (SNR) by about 10 dB in both simulation and experiments. Moreover, the improved 2D-SAFT algorithm is accelerated by a graphical processing unit that reduces the long period of reconstruction to only a few seconds. The proposed 2D-SAFT is demonstrated to outperform previous reported 1D SAFT in the aspects of improving the depth of focus, imaging resolution, and SNR with fast computational efficiency. This work facilitates future studies on in vivo deeper and high-resolution photoacoustic microscopy beyond several centimeters. Published version 2019-10-31T05:03:31Z 2019-12-06T21:37:49Z 2019-10-31T05:03:31Z 2019-12-06T21:37:49Z 2018 Journal Article Liu, S., Feng, X., Gao, F., Jin, H., Zhang, R., Luo, Y., & Zheng, Y. (2018). GPU-accelerated two dimensional synthetic aperture focusing for photoacoustic microscopy. APL Photonics, 3(2), 026101-. doi:10.1063/1.5005145 https://hdl.handle.net/10356/104699 http://hdl.handle.net/10220/50300 10.1063/1.5005145 en APL Photonics © 2018 The author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license 12 p. application/pdf
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Photoacoustic Effects
Acoustic Transducers
DRNTU::Engineering::Electrical and electronic engineering
spellingShingle Photoacoustic Effects
Acoustic Transducers
DRNTU::Engineering::Electrical and electronic engineering
Liu, Siyu
Feng, Xiaohua
Gao, Fei
Jin, Haoran
Zhang, Ruochong
Luo, Yunqi
Zheng, Yuanjin
GPU-accelerated two dimensional synthetic aperture focusing for photoacoustic microscopy
description Acoustic resolution photoacoustic microscopy (AR-PAM) generally suffers from limited depth of focus, which had been extended by synthetic aperture focusing techniques (SAFTs). However, for three dimensional AR-PAM, current one dimensional (1D) SAFT and its improved version like cross-shaped SAFT do not provide isotropic resolution in the lateral direction. The full potential of the SAFT remains to be tapped. To this end, two dimensional (2D) SAFT with fast computing architecture is proposed in this work. Explained by geometric modeling and Fourier acoustics theories, 2D-SAFT provide the narrowest post-focusing capability, thus to achieve best lateral resolution. Compared with previous 1D-SAFT techniques, the proposed 2D-SAFT improved the lateral resolution by at least 1.7 times and the signal-to-noise ratio (SNR) by about 10 dB in both simulation and experiments. Moreover, the improved 2D-SAFT algorithm is accelerated by a graphical processing unit that reduces the long period of reconstruction to only a few seconds. The proposed 2D-SAFT is demonstrated to outperform previous reported 1D SAFT in the aspects of improving the depth of focus, imaging resolution, and SNR with fast computational efficiency. This work facilitates future studies on in vivo deeper and high-resolution photoacoustic microscopy beyond several centimeters.
author2 School of Electrical and Electronic Engineering
author_facet School of Electrical and Electronic Engineering
Liu, Siyu
Feng, Xiaohua
Gao, Fei
Jin, Haoran
Zhang, Ruochong
Luo, Yunqi
Zheng, Yuanjin
format Article
author Liu, Siyu
Feng, Xiaohua
Gao, Fei
Jin, Haoran
Zhang, Ruochong
Luo, Yunqi
Zheng, Yuanjin
author_sort Liu, Siyu
title GPU-accelerated two dimensional synthetic aperture focusing for photoacoustic microscopy
title_short GPU-accelerated two dimensional synthetic aperture focusing for photoacoustic microscopy
title_full GPU-accelerated two dimensional synthetic aperture focusing for photoacoustic microscopy
title_fullStr GPU-accelerated two dimensional synthetic aperture focusing for photoacoustic microscopy
title_full_unstemmed GPU-accelerated two dimensional synthetic aperture focusing for photoacoustic microscopy
title_sort gpu-accelerated two dimensional synthetic aperture focusing for photoacoustic microscopy
publishDate 2019
url https://hdl.handle.net/10356/104699
http://hdl.handle.net/10220/50300
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