Desymmetrisation of 1,3-diols and their diacetates under enzymatic heterogeneous catalysis and synthesis of 1,3-diols under continuous flow conditions

• Main Author: Pamarthy, Varsha Siri
• Other Authors: Zaher Judeh
• Format: Theses and Dissertations
• Language: English
• Published: 2019
• Subjects: DRNTU::Engineering::Chemical engineering::Chemicals and manufacture; DRNTU::Science::Chemistry::Physical chemistry::Catalysis
• Online Access: https://hdl.handle.net/10356/104795; http://hdl.handle.net/10220/48650
• Institution: Nanyang Technological University

Piperidones are present in many biologically important compounds. One of the key steps in the synthesis of one such piperidone, N-benzyl-5- methoxypiperidone, is the desymmetrisation of 1,3-diol, N-Benzyl-5-hydroxy-4- (hydroxymethyl)pentanamide or 1,3-diacetate, N-Benzyl-5-acetoxy-4- (acetoxymethyl)...