CTSH regulates : cell function and disease progression in newly diagnosed type 1 diabetes patients

• Main Authors: Reinheckel, Thomas, Herrath, Matthias von, Fløyel, Tina, Brorsson, Caroline, Nielsen, Lotte B., Miani, Michela, Bang-Berthelsen, Claus Heiner, Friedrichsen, Martin, Overgaard, Anne Julie, Berchtold, Lukas A., Wiberg, Anna, Poulsen, Pernille, Hansen, Lars, Rosinger, Silke, Boehm, Bernhard O., Ram, Ramesh, Nguyen, Quang, Mehta, Munish, Morahan, Grant, Concannon, Patrick, Bergholdt, Regine, Nielsen, Jens H., Vaag, Allan, Eizirik, Decio Laks, Mortensen, Henrik B., Størling, Joachim, Pociot, Flemming
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2014
• 主題: DRNTU::Science::Biological sciences
• 在線閱讀: https://hdl.handle.net/10356/104802; http://hdl.handle.net/10220/20294
• 機構: Nanyang Technological University

Over 40 susceptibility loci have been identified for type 1 diabetes (T1D). Little is known about how these variants modify disease risk and progression. Here, we combined in vitro and in vivo experiments with clinical studies to determine how genetic variation of the candidate gene cathepsin H (CTS...