Streptolysin-induced endoplasmic reticulum stress promotes Group A Streptococcal host-associated biofilm formation and necrotising fasciitis

• Main Authors: Vajjala, Anuradha, Biswas, Debabrata, Tay, Wei Hong, Hanski, Emanuel, Kline, Kimberly Ann
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Biofilms; ER Stress; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/104884; http://hdl.handle.net/10220/48125
• Institution: Nanyang Technological University

Group A Streptococcus (GAS) is a human pathogen that causes infections ranging from mild to fulminant and life‐threatening. Biofilms have been implicated in acute GAS soft‐tissue infections such as necrotising fasciitis (NF). However, most in vitro models used to study GAS biofilms have been designe...