Coronavirus infection, ER stress, apoptosis and innate immunity

• Main Authors: Fung, To S., Liu, Ding X.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Microbiology
• Online Access: https://hdl.handle.net/10356/105072; http://hdl.handle.net/10220/20388
• Institution: Nanyang Technological University

The replication of coronavirus, a family of important animal and human pathogens, is closely associated with the cellular membrane compartments, especially the endoplasmic reticulum (ER). Coronavirus infection of cultured cells was previously shown to cause ER stress and induce the unfolded protein...