Collective synthesis of 4-hydroxy-2-pyridone alkaloids and their antiproliferation activities

• Main Authors: Ding, Feiqing, Leow, Min Li, Ma, Jimei, William, Ronny, Liao, Hongze, Liu, Xue-Wei
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Chemistry
• Online Access: https://hdl.handle.net/10356/105141; http://hdl.handle.net/10220/20459; http://dx.doi.org/10.1002/asia.201402466
• Institution: Nanyang Technological University

A collective synthesis of 4-hydroxy-2-pyridone alkaloids—specifically, pretenellin B, prebassianin B, farinosone A, militarione D, pyridovericin, and torrubiellone C—has been achieved. Key steps include using a strategic convergent method to synthesize the densely substituted pyridone key intermedia...