Electrical circuit modeling and analysis of microwave acoustic interaction with biological tissues
Purpose: Numerical study of microwave imaging and microwave-induced thermoacoustic imaging utilizes finite difference time domain (FDTD) analysis for simulation of microwave and acoustic interaction with biological tissues, which is time consuming due to complex grid-segmentation and numerous calcu...
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sg-ntu-dr.10356-1052782019-12-06T21:48:40Z Electrical circuit modeling and analysis of microwave acoustic interaction with biological tissues Gao, Fei Zheng, Qian Zheng, Yuanjin School of Electrical and Electronic Engineering DRNTU::Science::Medicine::Tissue engineering Purpose: Numerical study of microwave imaging and microwave-induced thermoacoustic imaging utilizes finite difference time domain (FDTD) analysis for simulation of microwave and acoustic interaction with biological tissues, which is time consuming due to complex grid-segmentation and numerous calculations, not straightforward due to no analytical solution and physical explanation, and incompatible with hardware development requiring circuit simulator such as SPICE. In this paper, instead of conventional FDTD numerical simulation, an equivalent electrical circuit model is proposed to model the microwave acoustic interaction with biological tissues for fast simulation and quantitative analysis in both one and two dimensions (2D). Methods: The equivalent circuit of ideal point-like tissue for microwave-acoustic interaction is proposed including transmission line, voltage-controlled current source, envelop detector, and resistor-inductor-capacitor (RLC) network, to model the microwave scattering, thermal expansion, and acoustic generation. Based on which, two-port network of the point-like tissue is built and characterized using pseudo S-parameters and transducer gain. Two dimensional circuit network including acoustic scatterer and acoustic channel is also constructed to model the 2D spatial information and acoustic scattering effect in heterogeneous medium. Results: Both FDTD simulation, circuit simulation, and experimental measurement are performed to compare the results in terms of time domain, frequency domain, and pseudo S-parameters characterization. 2D circuit network simulation is also performed under different scenarios including different sizes of tumors and the effect of acoustic scatterer. Conclusions: The proposed circuit model of microwave acoustic interaction with biological tissue could give good agreement with FDTD simulated and experimental measured results. The pseudo S-parameters and characteristic gain could globally evaluate the performance of tumor detection. The 2D circuit network enables the potential to combine the quasi-numerical simulation and circuit simulation in a uniform simulator for codesign and simulation of a microwave acoustic imaging system, bridging bioeffect study and hardware development seamlessly. Accepted version 2014-09-11T07:41:04Z 2019-12-06T21:48:40Z 2014-09-11T07:41:04Z 2019-12-06T21:48:40Z 2014 2014 Journal Article Gao, F., Zheng, Q., & Zheng, Y. (2014). Electrical circuit modeling and analysis of microwave acoustic interaction with biological tissues. Medical Physics, 41(5), 053302-. 0094-2405 https://hdl.handle.net/10356/105278 http://hdl.handle.net/10220/20507 http://dx.doi.org/10.1118/1.4871783 en Medical physics © 2014 American Association of Physicists in Medicine. This is the author created version of a work that has been peer reviewed and accepted for publication by Medical Physics, American Association of Physicists in Medicine. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [DOI: http://dx.doi.org/10.1118/1.4871783]. 34 p. application/pdf |
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DRNTU::Science::Medicine::Tissue engineering Gao, Fei Zheng, Qian Zheng, Yuanjin Electrical circuit modeling and analysis of microwave acoustic interaction with biological tissues |
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Purpose:
Numerical study of microwave imaging and microwave-induced thermoacoustic imaging utilizes finite difference time domain (FDTD) analysis for simulation of microwave and acoustic interaction with biological tissues, which is time consuming due to complex grid-segmentation and numerous calculations, not straightforward due to no analytical solution and physical explanation, and incompatible with hardware development requiring circuit simulator such as SPICE. In this paper, instead of conventional FDTD numerical simulation, an equivalent electrical circuit model is proposed to model the microwave acoustic interaction with biological tissues for fast simulation and quantitative analysis in both one and two dimensions (2D).
Methods:
The equivalent circuit of ideal point-like tissue for microwave-acoustic interaction is proposed including transmission line, voltage-controlled current source, envelop detector, and resistor-inductor-capacitor (RLC) network, to model the microwave scattering, thermal expansion, and acoustic generation. Based on which, two-port network of the point-like tissue is built and characterized using pseudo S-parameters and transducer gain. Two dimensional circuit network including acoustic scatterer and acoustic channel is also constructed to model the 2D spatial information and acoustic scattering effect in heterogeneous medium.
Results:
Both FDTD simulation, circuit simulation, and experimental measurement are performed to compare the results in terms of time domain, frequency domain, and pseudo S-parameters characterization. 2D circuit network simulation is also performed under different scenarios including different sizes of tumors and the effect of acoustic scatterer.
Conclusions:
The proposed circuit model of microwave acoustic interaction with biological tissue could give good agreement with FDTD simulated and experimental measured results. The pseudo S-parameters and characteristic gain could globally evaluate the performance of tumor detection. The 2D circuit network enables the potential to combine the quasi-numerical simulation and circuit simulation in a uniform simulator for codesign and simulation of a microwave acoustic imaging system, bridging bioeffect study and hardware development seamlessly. |
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School of Electrical and Electronic Engineering |
author_facet |
School of Electrical and Electronic Engineering Gao, Fei Zheng, Qian Zheng, Yuanjin |
format |
Article |
author |
Gao, Fei Zheng, Qian Zheng, Yuanjin |
author_sort |
Gao, Fei |
title |
Electrical circuit modeling and analysis of microwave acoustic interaction with biological tissues |
title_short |
Electrical circuit modeling and analysis of microwave acoustic interaction with biological tissues |
title_full |
Electrical circuit modeling and analysis of microwave acoustic interaction with biological tissues |
title_fullStr |
Electrical circuit modeling and analysis of microwave acoustic interaction with biological tissues |
title_full_unstemmed |
Electrical circuit modeling and analysis of microwave acoustic interaction with biological tissues |
title_sort |
electrical circuit modeling and analysis of microwave acoustic interaction with biological tissues |
publishDate |
2014 |
url |
https://hdl.handle.net/10356/105278 http://hdl.handle.net/10220/20507 http://dx.doi.org/10.1118/1.4871783 |
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1681036592138944512 |