PTEN-opathies : from biological insights to evidence-based precision medicine

• Main Authors: Yehia, Lamis, Ngeow, Joanne, Eng, Charis
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2019
• Subjects: Akt Signaling; Phosphatidylinositol 3,4,5-Trisphosphate; DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/105339; http://hdl.handle.net/10220/48638
• Institution: Nanyang Technological University

The tumor suppressor phosphatase and tensin homolog (PTEN) classically counteracts the PI3K/AKT/mTOR signaling cascade. Germline pathogenic PTEN mutations cause PTEN hamartoma tumor syndrome (PHTS), featuring various benign and malignant tumors, as well as neurodevelopmental disorders such as autism...