Functional homogeneity and specificity of topological modules in human proteome

• Main Authors: Kaalia, Rama, Rajapakse, Jagath Chandana
• Other Authors: School of Computer Science and Engineering
• Format: Article
• Language: English
• Published: 2019
• Subjects: Topological Modules; Functional Modules; DRNTU::Engineering::Computer science and engineering
• Online Access: https://hdl.handle.net/10356/105491; http://hdl.handle.net/10220/48724; http://dx.doi.org/10.1186/s12859-018-2549-8
• Institution: Nanyang Technological University

Background: Functional modules in protein-protein interaction networks (PPIN) are defined by maximal sets of functionally associated proteins and are vital to understanding cellular mechanisms and identifying disease associated proteins. Topological modules of the human proteome have been shown to b...