Phosphatidylserine synthesis is essential for viability of the human fungal pathogen Cryptococcus neoformans

• Main Authors: Konarzewska, Paulina, Wang, Yina, Han, Gil-Soo, Goh, Kwok Jian, Gao, Yong-Gui, Carman, George M., Xue, Chaoyang
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Phospholipid Metabolism; DRNTU::Science::Biological sciences; Phosphatidylserine
• Online Access: https://hdl.handle.net/10356/105546; http://hdl.handle.net/10220/47823
• Institution: Nanyang Technological University

Phospholipids are an integral part of the cellular membrane structure and can be produced by a de novo biosynthetic pathway and, alternatively, by the Kennedy pathway. Studies in several yeast species have shown that the phospholipid phosphatidylserine (PS) is synthesized from CDP-diacylglycerol and...