A programmable lipid-polymer hybrid nanoparticle system for localized, sustained antibiotic delivery to Gram-positive and Gram-negative bacterial biofilms

• Main Authors: Baek, Jong-Suep, Tan, Chuan Hao, Ng, Noele Kai Jing, Yeo, Yee Phan, Rice, Scott A., Loo, Joachim Say Chye
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2019
• Subjects: Bacterial Biofilms; Engineering::Materials; Microbial Infection
• Online Access: https://hdl.handle.net/10356/105622; http://hdl.handle.net/10220/50260
• Institution: Nanyang Technological University

Bacteria enmeshed in an extracellular matrix, biofilms, exhibit enhanced antibiotic tolerance. Coupled with the rapid emergence of multidrug-resistant strains, the current cohorts of antibiotics are becoming ineffective. Alternative antimicrobial approaches are therefore urgently needed to overcome...